منابع مشابه
Protein Profiling of Preeclampsia Placental Tissues
Preeclampsia is a multi-system disorder involved in pregnancy without an effective treatment except delivery. The precise pathogenesis of this complicated disorder is still not completely understood. The objective of this study is to evaluate the alterations of protein expression and phosphorylations that are important in regulating placental cell function in preterm and term preeclampsia. Usin...
متن کاملPlacental expression profiling in preeclampsia: local overproduction of hemoglobin may drive pathological changes.
OBJECTIVE To create a library enriched in cDNAs from preeclamptic placentas to print onto microarrays for placental profiling of preeclampsia (PE) and high risk pregnancies. DESIGN Prospective study. SETTING University women's clinic and academic research laboratory. PATIENT(S) Ten patients with PE, 5 with PE and bilateral notching, 5 with bilateral notching without PE, and 15 normotensiv...
متن کاملEvidence by molecular profiling for a placental origin of infantile hemangioma.
The origin of the pathogenic endothelial cells in common infantile hemangioma is unknown. We show here that the transcriptomes of human placenta and infantile hemangioma are sufficiently similar to suggest a placental origin for this tumor, expanding on recent immunophenotypical studies that have suggested this possibility [North, P. E., et al. (2001) Arch. Dermatol. 137, 559-570]. The transcri...
متن کاملUnsupervised Placental Gene Expression Profiling Identifies Clinically Relevant Subclasses of Human Preeclampsia.
Preeclampsia (PE) is a complex, hypertensive disorder of pregnancy, demonstrating considerable variability in maternal symptoms and fetal outcomes. Unfortunately, prior research has not accounted for this variability, resulting in a lack of robust biomarkers and effective treatments for PE. Here, we created a large (N=330) clinically relevant human placental microarray data set, consisting of 7...
متن کاملApplication of gene expression profiling to the study of placental and fetal function
Background: One of the key biological principles that differentiate mammals from other phyla is the presence of the placenta. This is a unique and complex tissue that plays an essential role in the development of the fetus and has both short terms effects in terms of reproductive efficiency, and long term effects in terms of adult onset diseases exacerbated by an inadequate fetal environment. Y...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genome Biology
سال: 2001
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20011108-01